TxGNN: TxGNN: Foundation Model for Clinician-Centered Zero-Shot Drug Repurposing Across 17,000 Rare Diseases

TxGNN is an open-source clinical AI foundation model engineered for Multi-System Rare Diseases & Oncology and Biomedical Knowledge Graphs & Molecular Networks applications.

Key Features

• Architecture: Domain-hardened neural network optimized for offline hospital edge inference.
• License: Apache 2.0 Open Source.
• Benchmarks: Validated against Therapeutics Data Commons (TDC), Disease Ontology, DrugBank, ClinicalTrials.gov.
• Repository: https://github.com/mims-harvard/TxGNN

Verification & Deployment

Available for air-gapped deployment in hospital IT environments, clinical research laboratories, and healthcare edge devices.